Pre-clinical studies in humans and mice suggest that CBD can prevent SARS-CoV-2 replication in the early stages of infection. 

This study published in the journal Science Advances reports that CBD showed a significant negative association with positive SARS-CoV-2 tests in a national sample of medical records of patients taking the FDA-approved drug to treat epilepsy.

Researchers at the University of Chicago, on the other hand, reject self-administration of this compound for Covid-19: more research is needed and questions remain about the optimal dose, formulation or mode of administration, they say.


Caution but promising progress

An interdisciplinary team of researchers at the University of Chicago, led by Marsha Rosner, has found evidence that cannabidiol, or CBD, a product of the cannabis plant, can inhibit COVID-19 virus infection in human cells and mice.

More studies and research are being added as the team of scientists led by Long Chi Nguyen advocate for rigorous clinical trials to evaluate the potential of CBD as a therapeutic intervention for Covid-19, including its possible long-term effects.

This team found that tetrahydrocannabinol (THC), the main psychoactive compound in cannabis sativa and indica, grown for use as marijuana, could strongly counteract the antiviral effects of CBD that they observed. The authors state that this finding “essentially eliminates the feasibility of marijuana serving as an effective source of antiviral CBD“.

Researchers treated human lung cancer cells expressing the ACE2 receptor, the key entry point for SARS-CoV-2, with CBD two hours before infection with the virus. 

After 48 hours, the team observed strong inhibition of viral replication, with no observable toxic effects.

The researchers repeated these experiments with two other types of human cells and three variants of the virus (Alpha, Beta and Gamma), all with comparable results.

Nguyen and his team also tested their results in mice expressing the human ACE2 receptor. At both the lowest and highest doses, CBD reduced viral load and none of the mice lost weight or showed signs of clinical disease. “These results establish the preclinical efficacy – in tissues and animal models – of CBD as an antiviral drug for SARS-CoV-2 during the early stages of infection“, conclude the authors of the paper.

CBD could prevent COVID from making copies of itself

Using small doses of highly purified CBD that approximate those patients receive in an oral medication already approved for severe epilepsy, Rosner and colleagues found that CBD did not prevent the coronavirus from infecting cells in test tubes.  

Instead, it acted soon after the virus entered cells, preventing it from making copies of itself, partly through effects on the inflammatory protein interferon. They found similar effects in infected mice, according to a report published in Science Advances. 

Rosner’s team is considering a clinical trial that would likely focus on asymptomatic or mild cases of COVID-19. 


CBGA and CBDA as potential cannabidoids to prevent COVID 

According to a study published in the Journal of Natural Products by Richard van Breemen, a researcher at the Oregon State Hemp Innovation Center (USA), CBGA (cannabigerolic acid) and CBDA (cannabidiolic acid) may prevent COVID because they can bind to the spike protein of the coronavirus, preventing it from attaching to cells.

The ‘spike’ protein would bind to the cannabis compound rather than the cells, which may offer new avenues to prevent and treat the disease.

“CBGA and CBDA are abundant in hemp and many hemp extracts. Any part of the infection and replication cycle is a potential target for antiviral intervention and the connection of the receptor binding domain of the ‘spike’ protein to the human cell surface ACE2 receptor is a critical step in this cycle,” Breemen explains. 

Finally, the researcher details that his data show that CBDA and CBGA are effective against the two variants tested, and the trend is expected to extend to other existing and future variants. 



The truth is that COVID is a virus about which much remains to be learned, but more and more scientific studies are being conducted with the aim of seeking possible prevention and reproduction of the virus. 

In our opinion, an alternative could be to produce an oil with CBD and CBG alpha acids with several cannabinoids that enhance each other to generate the entourage effect (the “extra” effect produced by the synergy between the cannabinoids and the other molecules of cannabis).  

Will CBD be an ally in this battle remains to be seen. 



CBC (cannabichromene)

What is CBC? CBC (cannabichromene) is one of the six main cannabinoids produced in both hemp and marijuana and its origin is CBGA (cannabigerol). The hemp plant with selected CBG genetics produces CBGA, which can be considered the "cannabinoid stem cell". From there,...

CBN and melatonin based sleep oil

CBN is the best cannabinoid for sleep and that is why we have developed a sleep oil designed for people who have problems with insomnia. Many adults experience short-term acute insomnia, lasting a few days or weeks. It is usually due to stress or a traumatic event....

CBG and our research project to treat lung diseases

In this article we want to refer to CBG, the root of cannabinoids, its difference with CBD and finally inform you about our CBG research project aimed at developing products to treat lung-related diseases. What is CBG? CBG is one of the least studied cannabinoids due...


CBD oil, scientifically known as cannabidiol oil, has been marketed on a large scale to treat different ailments, from inflammation and chronic pain to anxiety and insomnia. In this article we want to highlight the most relevant aspects of it and about its...

What is Full Spectrum CBD oil?

What is Full Spectrum CBD oil? Full Spectrum CBD oil is a product derived from the hemp plant that contains a wide variety of cannabinoids and other natural compounds found in the cannabis plant, including CBD (cannabidiol), THC (tetrahydrocannabinol), CBG...

Broad spectrum CBD oil

Before we dive into broad spectrum CBD oil, let's talk about CBD oil, which is a well-known and in-demand cannabinoid cannabis extract. CBD, one of many cannabinoids present in hemp and cannabis plants, is a water insoluble and oil soluble organic compound. You can...

CBG oil: benefits and adverse effects

In this blog post, we want to remind what CBG is, and specifically, we will focus on CBG oil, its benefits, and its effects, as well as describe how we make it and where you can find it. What is CBG? CBG is one of the least studied cannabinoids due to its low presence...

CBD legalisation in Thailand

Thailand has legalised the cultivation and use of cannabis after decades of harsh anti-drug policies, which punished drug offences with long prison sentences or even the death penalty. The new law, passed in June 2022, limits the use of the plant for medical and...